Cell Adhesion Strength Indicates the Antithrombogenicity of Poly(2-methoxyethyl acrylate) (PMEA): Potential Candidate for Artificial Small-Diameter Blood Vessel

Poly(2-methoxyethyl acrylate) (PMEA) is a US FDA-approved biocompatible polymer, although there insufficient work on human umbilical vein endothelial cells (HUVECs) and platelet interaction analysis PMEA-analogous polymers. In this study, we extensively investigated HUVEC–polymer platelet–polymer behavior by measuring the adhesion strength using single-cell force spectroscopy. Furthermore, hydration layer of polymer interface was observed frequency-modulation atomic microscopy. We found that can attach spread PMEA surface with strong compared to other analogous layers polymers were closely related their weak behavior. Based our results, it be concluded promising candidate for construction artificial small-diameter blood vessels owing presence IW interface.